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Over the last few decades, there has been an explosion of scientific publications reporting the many and varied roles of transient receptor potential (TRP) ion channels in physiological and pathological systems throughout the body. The aim of this review is to summarize the existing literature on the role of TRP channels in the lungs and discuss what is known about their function under normal and diseased conditions. The review will focus mainly on the pathogenesis and symptoms of asthma and chronic obstructive pulmonary disease and the role of four members of the TRP family: TRPA1, TRPV1, TRPV4 and TRPM8. We hope that the article will help the reader understand the role of TRP channels in the normal airway and how their function may be changed in the context of respiratory disease.

Original publication




Journal article


British journal of pharmacology

Publication Date





2593 - 2607


Respiratory Pharmacology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.


Lung, Animals, Humans, Asthma, Pulmonary Disease, Chronic Obstructive, Anti-Asthmatic Agents, Ligands, Signal Transduction, Membrane Transport Modulators, Transient Receptor Potential Channels