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We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.

Original publication




Journal article


Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Publication Date





National Infection Service, Public Health England, London, United Kingdom.


Humans, Chlamydia trachomatis, Chlamydia Infections, False Positive Reactions, Mass Screening, Prevalence, Nucleic Acid Amplification Techniques, Adult, England, Female, Male, Genetic Variation, Young Adult