Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

BACKGROUND:Weight loss is a milestone in the prevention of chronic diseases associated with high morbility and mortality in industrialized countries. Very-low calorie ketogenic diets (VLCKDs) are increasingly used in clinical practice for weight loss and management of obesity-related comorbidities. Despite evidence on the clinical benefits of VLCKDs is rapidly emerging, some concern still exists about their potential risks and their use in the long-term, due to paucity of clinical studies. Notably, there is an important lack of guidelines on this topic, and the use and implementation of VLCKDs occurs vastly in the absence of clear evidence-based indications. PURPOSE:We describe here the biochemistry, benefits and risks of VLCKDs, and provide recommendations on the correct use of this therapeutic approach for weight loss and management of metabolic diseases at different stages of life.

Original publication

DOI

10.1007/s40618-019-01061-2

Type

Journal article

Journal

Journal of endocrinological investigation

Publication Date

11/2019

Volume

42

Pages

1365 - 1386

Addresses

Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Via di Val Cannuta 247, 00166, Rome, Italy. massimiliano.caprio@sanraffaele.it.

Keywords

Cardiovascular Endocrinology Club of the Italian Society of Endocrinology, Humans, Metabolic Diseases, Obesity, Diet, Reducing, Consensus, Endocrinology, Societies, Medical, Diet, Ketogenic