Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The past five decades have seen significant progress in our understanding of human hematopoiesis. This has in part been due to the unprecedented development of advanced technologies, which have allowed the identification and characterization of rare subsets of human hematopoietic stem and progenitor cells and their lineage trajectories from embryonic through to adult life. Additionally, surrogate in vitro and in vivo models, although not fully recapitulating human hematopoiesis, have spurred on these scientific advances. These approaches have heightened our knowledge of hematological disorders and diseases and have led to their improved diagnosis and therapies. Here, we review human hematopoiesis at each end of the age spectrum, during embryonic and fetal development and on aging, providing exemplars of recent progress in deciphering the increasingly complex cellular and molecular hematopoietic landscapes in health and disease. This review concludes by highlighting links between chronic inflammation and metabolic and epigenetic changes associated with aging and in the development of clonal hematopoiesis.

Original publication

DOI

10.3390/ijms23073675

Type

Journal article

Journal

Int J Mol Sci

Publication Date

27/03/2022

Volume

23

Keywords

aging, childhood leukemias, clonal hematopoiesis of indeterminate potential, development, hematopoietic stem cells, inflamm-aging, metabolism, single-cell transcriptomics, Aging, Clonal Hematopoiesis, Epigenesis, Genetic, Hematopoiesis, Hematopoietic Stem Cells, Humans