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Because of its complex geometry, assessment of right ventricular (RV) function is more difficult than it is for the left ventricle (LV). Because gene-targeted mouse models of cardiomyopathy may involve remodeling of the right heart, the purpose of this study was to develop high-resolution functional magnetic resonance imaging (MRI) for in vivo quantification of RV volumes and global function in mice. Thirty-three mice of various age were studied under isoflurane anesthesia by electrocardiogram-triggered cine-MRI at 7 T. MRI revealed close correlations between RV and LV stroke volume and cardiac output (r = 0.97, P < 0.0001 each). Consistent with human physiology, murine RV end-diastolic and end-systolic volumes were significantly higher compared with LV volumes (P < 0.05 each). MRI in mice with LV heart failure due to myocardial infarction revealed significant structural and functional changes of the RV, indicating RV dysfunction. Hence, MRI allows for the quantification of RV volumes and global systolic function with high accuracy and bears the potential to evaluate mechanisms of RV remodeling in mouse models of heart failure.

Original publication

DOI

10.1152/ajpheart.00802.2001

Type

Journal article

Journal

Am J Physiol Heart Circ Physiol

Publication Date

09/2002

Volume

283

Pages

H1065 - H1071

Keywords

Animals, Disease Models, Animal, Female, Heart Failure, Magnetic Resonance Imaging, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Stroke Volume, Ventricular Function, Left, Ventricular Function, Right, Ventricular Remodeling