Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The pulsatile release of hormone is obligatory for the control of a range of important body homeostatic functions. To generate these pulses, endocrine organs have developed finely regulated mechanisms to modulate blood flow both to meet the metabolic demand associated with intense endocrine cell activity and to ensure the temporally precise uptake of secreted hormone into the bloodstream. With a particular focus on the pituitary gland as a model system, we review here the importance of the interplay between blood flow regulation and oxygen tensions in the functioning of endocrine systems, and the known regulatory signals involved in the modification of flow patterns under both normal physiological and pathological conditions.

Original publication

DOI

10.1111/j.1460-9568.2010.07525.x

Type

Journal article

Journal

Eur J Neurosci

Publication Date

2010

Volume

32

Pages

2087 - 2095

Keywords

Animals Endocrine System/blood supply/metabolism Humans Oxygen/*blood Oxygen Consumption Partial Pressure Pituitary Gland, Anterior/*blood supply/cytology Pituitary Hormones, Anterior/metabolism Regional Blood Flow/*physiology