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Myelodysplastic syndromes (MDS) have a major impact on quality of life (QoL). We performed a post hoc analysis of two multicenter trials of azacitidine-based disease-modifying therapy for patients with MDS and low blast count acute myeloid leukemia (AML), to identify factors associated with QoL. 231 patients were included (median age 70 years). At baseline, higher initial hemoglobin, but not neutrophil or platelet count, was associated with better global QoL and physical function (p 

Original publication




Journal article


Leuk Lymphoma

Publication Date



1 - 8


Myelodysplastic syndrome, acute myeloid leukemia, azacitidine, hemoglobin, quality of life, red cell transfusion