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Personalized medicine or individualized therapy promises a paradigm shift in healthcare. This is particularly true in complex and multifactorial diseases such as diabetes and the multitude of related pathophysiological complications. Diabetic cardiomyopathy represents an emerging condition that could be effectively treated if better diagnostic and, in particular, better therapeutic monitoring tools were available. In this study, we investigate the ability to differentiate low and high doses of metabolically targeted therapy in an obese type-2 diabetic rat model. Low dose dichloroacetate (DCA) treatment was associated with an increased lactate production, while no or little change was seen in the bicarbonate production. High dose DCA treatment was associated with a significant metabolic switch towards increased bicarbonate production. These findings support further studies using hyperpolarized [1-13 C]-pyruvate MRI to differentiate treatment effects and thus allow for personalized titration of therapeutics.

Original publication

DOI

10.1002/nbm.4678

Type

Journal article

Journal

NMR in biomedicine

Publication Date

27/12/2021

Addresses

MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.