INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): study protocol for a randomized controlled trial.
Song L., Chen C., Chen X., Guo Y., Liu F., Lin Y., Billot L., Li Q., Liu H., Si L., Ouyang M., Arima H., Bath PM., Ford GA., Robinson T., Sandset EC., Saver JL., Sprigg N., van der Worp HB., Zhang C., Yang J., Li G., Anderson CS., INTERACT4 investigators None.
BACKGROUND: Early pre-hospital initiation of blood pressure (BP) lowering could improve outcomes for patients with acute stroke, by reducing hematoma expansion in intracerebral hemorrhage (ICH), and time to reperfusion treatment and risk of intracranial hemorrhage in ischemic stroke (IS). We present the design of the fourth INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4). METHODS: A multi-center, ambulance-delivered, prospective, randomized, open-label, blinded endpoint (PROBE) assessed trial of pre-hospital BP lowering in 3116 hypertensive patients with suspected acute stroke at 50+ sites in China. Patients are randomized through a mobile phone digital system to intensive BP lowering to a target systolic BP of