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The viruses HIV-1, Epstein-Barr virus (EBV), cytomegalovirus (CMV) and hepatitis C virus (HCV) are characterized by the establishment of lifelong infection in the human host, where their replication is thought to be tightly controlled by virus-specific CD8+ T cells. Here we present detailed studies of the differentiation phenotype of these cells, which can be separated into three distinct subsets based on expression of the costimulatory receptors CD28 and CD27. Whereas CD8+ T cells specific for HIV, EBV and HCV exhibit similar characteristics during primary infection, there are significant enrichments at different stages of cellular differentiation in the chronic phase of persistent infection according to the viral specificity, which suggests that distinct memory T-cell populations are established in different virus infections. These findings challenge the current definitions of memory and effector subsets in humans, and suggest that ascribing effector and memory functions to subsets with different differentiation phenotypes is no longer appropriate.

Original publication

DOI

10.1038/nm0402-379

Type

Journal article

Journal

Nat Med

Publication Date

04/2002

Volume

8

Pages

379 - 385

Keywords

Adolescent, Adult, Aged, Antigens, CD27, Antigens, CD28, Antigens, CD45, CD8-Positive T-Lymphocytes, Cell Differentiation, Child, Child, Preschool, Cytomegalovirus Infections, Cytotoxins, Epstein-Barr Virus Infections, HIV Infections, HIV-1, Hepatitis C, Chronic, Humans, Immunologic Memory, Middle Aged, Phenotype, Receptors, CCR7, Receptors, Chemokine, T-Lymphocyte Subsets, Virus Diseases