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BACKGROUND AND AIMS: SARS-Cov-2 predisposes patients to thrombotic complications, due to excessive inflammation, endothelial dysfunction, platelet activation, and coagulation/fibrinolysis disturbances. The aim of the present study was to evaluate clinical characteristics and prognostic impact of SARS-CoV-2 positivity among STEMI patients undergoing primary percutaneous coronary intervention (PPCI). METHODS: We selected SARS-CoV-2 positive patients included in the ISACS-STEMI COVID-19, a retrospective multicenter European registry including 6609 STEMI patients treated with PPCI from March 1st until April 30th, in 2019 and 2020. As a reference group, we randomly sampled 5 SARS-Cov-2 negative patients per each SARS-CoV-2 positive patient, individually matched for age, sex, and hospital/geographic area. Study endpoints were in-hospital mortality, definite stent thrombosis, heart failure. RESULTS: Our population is represented by 62 positive SARS-CoV-2 positive patients who were compared with a matched population of 310 STEMI patients. No significant difference was observed in baseline characteristics or the modality of access to the PCI center. In the SARS-CoV-2 positive patients, the culprit lesion was more often located in the RCA (p 

Original publication

DOI

10.1016/j.atherosclerosis.2021.06.926

Type

Journal article

Journal

Atherosclerosis

Publication Date

09/2021

Volume

332

Pages

48 - 54

Keywords

SARS-CoV-2, ST segment elevation myocardial infarction, Thrombosis(please add them), COVID-19, Humans, Percutaneous Coronary Intervention, Registries, Reperfusion, Retrospective Studies, SARS-CoV-2, ST Elevation Myocardial Infarction, Treatment Outcome