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AIMS: To describe four cases of plasmablastic lymphoma arising in the unusual setting of a post-transplantation lymphoproliferative disorder (PTLD). METHODS AND RESULTS: Four cases were encountered over 2 years in human immunodeficiency virus (HIV)-negative patients following renal, heart or bone marrow transplantation. The cases were routinely processed and immunohistochemistry was performed. The cases showed blastic non-Hodgkin's lymphoma morphology and plasma cell-like immunophenotypic features: minimal or absent expression of leucocyte common antigen and CD20, variable CD79a and VS38 positivity. Monoclonal light chain restriction was also detected. CONCLUSIONS: The emphasis of this paper is to document further the occurrence of plasmablastic lymphomas in HIV- individuals and to expand the spectrum of PTLD.

Original publication

DOI

10.1111/j.1365-2559.2007.02870.x

Type

Journal article

Journal

Histopathology

Publication Date

12/2007

Volume

51

Pages

774 - 777

Keywords

Adult, Bone Marrow Transplantation, Epstein-Barr Virus Infections, HIV, Heart Transplantation, Herpesvirus 4, Human, Humans, Immunohistochemistry, Kidney Transplantation, Lymphoma, Large-Cell, Immunoblastic, Male, Middle Aged, Postoperative Complications