Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Many chronic diseases, including those classified as cardiovascular, neurodegenerative, or autoimmune, are characterized by persistent inflammation. The origin of this inflammation is mostly unclear, but it is typically mediated by inflammatory biomarkers, such as cytokines, and affected by both environmental and genetic factors. Recently circulating bacterial inflammagens such as lipopolysaccharide (LPS) have been implicated. We used a highly selective mouse monoclonal antibody to detect bacterial LPS in whole blood and/or platelet poor plasma of individuals with Parkinson's Disease, Alzheimer's type dementia, or Type 2 Diabetes Mellitus. Our results showed that staining is significantly enhanced (P 

Original publication

DOI

10.1038/s41598-018-35009-y

Type

Journal article

Journal

Scientific reports

Publication Date

14/11/2018

Volume

8

Addresses

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, Private Bag X1 Matieland, 7602, South Africa.

Keywords

Humans, Parkinson Disease, Alzheimer Disease, Diabetes Mellitus, Type 2, Inflammation, Amyloid, Lipopolysaccharides, Fibrin, Microscopy, Electron, Blood Specimen Collection, Protein Binding, Blood Coagulation, Aged, Middle Aged, Female, Male