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Dendritic cells (DCs) are sentinel cells of the immune system arising from hematopoietic stem cells. DCs play a key role in the regulation of both adaptive and innate lymphocyte responses. As such, experimental models enabling a thorough analysis of human DCs development and function are needed. Humanized mice models (termed collectively as HIS mice, or human immune system mice models) provide unique opportunities to model human hematopoiesis and tackle the function of human immune cell types in vivo. Here, we review experimental approaches enabling to recapitulate the ontogeny of DC subsets in HIS mice and discuss studies addressing the biology of human DC subsets implementing HIS mice models.

Original publication

DOI

10.1016/j.molimm.2020.07.005

Type

Journal article

Journal

Mol Immunol

Publication Date

09/2020

Volume

125

Pages

151 - 161

Keywords

Dendritic cells, Engineered stromal cells, Humanized mice, NSG, Animals, Dendritic Cells, Humans, Mice, Models, Animal