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A major barrier to successful allogeneic hematopoietic stem cell transplantation is graft-versus-host disease (GVHD). Until recently, the role of antigen presentation in the development of this disorder was unknown. The experimental finding that recipient antigen-presenting cells (APCs) were required for the development of CD8(+) T cell-dependent GVHD has led to a fundamental reappraisal of our ideas concerning the pathogenesis of this disease. Following transplantation, the origin (donor or recipient), number, lineage, and function of APCs within the recipient are altered significantly. Studies that test the influence of each of these factors upon graft-versus-host responses, including graft-versus-tumor responses, are beginning to emerge and suggest that APCs, such as dendritic cells, constitute a potential target for therapeutic manipulation.

Original publication

DOI

10.1089/15258160260194758

Type

Journal article

Journal

J Hematother Stem Cell Res

Publication Date

08/2002

Volume

11

Pages

601 - 616

Keywords

Dendritic Cells, Graft vs Host Disease, Humans, Stem Cell Transplantation, Transplantation, Homologous