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BACKGROUND: After allogeneic hematopoietic stem cell transplantation, donor T cells interact with an antigen-presenting cell environment that is distorted in number, level of activation, and origin. The role of antigen presentation in the development of chronic graft-versus host disease (cGVHD) is unknown. METHODS: The number and origin of peripheral blood immature myeloid (CD19- CD1c+) and plasmacytoid (BDCA-2+) dendritic cells (DCs) was determined in 30 patients at more than 100 days after allogeneic hematopoietic stem cell transplantation. RESULTS: Patients with cGVHD had significantly higher plasmacytoid DC numbers than individuals without this complication (9.1+/-2.0 x 10(6)/L versus 3.8+/-0.6 x 10(6)/L, =0.025). Chimerism studies demonstrated that DCs in patients with cGVHD were exclusively of donor origin, whereas persistence of host DCs was observed in some control patients. CONCLUSIONS: The antigen-presenting cell environment in patients with cGVHD, as represented by immature blood DCs, is of donor origin but distorted in terms of subset distribution.

Original publication

DOI

10.1097/01.TP.0000041783.34083.11

Type

Journal article

Journal

Transplantation

Publication Date

27/01/2003

Volume

75

Pages

221 - 225

Keywords

Adolescent, Adult, Antigens, CD1, Antigens, CD19, Cell Count, Chronic Disease, Dendritic Cells, Female, Glycoproteins, Graft vs Host Disease, HLA-DR Antigens, Humans, Male, Middle Aged