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Serological reactivity was analysed in plasma from 436 individuals with a history of disease compatible with COVID-19, including 256 who had been laboratory-confirmed with SARS-CoV-2 infection. Over 99% of laboratory-confirmed cases developed a measurable antibody response (254/256) and 88% harboured neutralising antibodies (226/256). Antibody levels declined over 3 months following diagnosis, emphasising the importance of the timing of convalescent plasma collections. Binding antibody measurements can inform selection of convalescent plasma donors with high neutralising antibody levels.

Original publication

DOI

10.2807/1560-7917.ES.2020.25.28.2001260

Type

Journal article

Journal

Euro Surveill

Publication Date

07/2020

Volume

25

Keywords

SARS-CoV-2, antibody response, convalescent plasma, high titre, neutralising antibodies, symptomatic infection, Adolescent, Adult, Aged, Antibodies, Neutralizing, Antibody Specificity, Betacoronavirus, Blood Donors, COVID-19, Coronavirus Infections, England, Humans, Immunization, Passive, Middle Aged, Pandemics, Pneumonia, Viral, SARS-CoV-2, Statistics, Nonparametric, Time Factors, Young Adult