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Limited studies have been reported about the function of low level of microsatellite instability (MSI-L) in cancer. The aim of our study is to unveil the prognostic role of MSI-L in gastric cancer (GC). One hundred nine patients with locally advanced GC (T3-4a, N+, M0) who underwent neoadjuvant chemotherapy plus gastrectomy with extended (D2) lymph node dissection were collected. Clinicopathological characteristics, tumour regression score, disease-free survival (DFS), and overall survival (OS) were analysed and correlated with the MSI status. The MSI status of 96 patients was identified (7 (7.3%) with MSI-H, 12 (12.5%) with MSI-L, and 77 (80.2%) with MSS). MSI-L was significantly correlated with perineural invasion (P = 0.009) and decreased MUC5AC expression (P = 0.042). Poor response to neoadjuvant chemotherapy in MSI-L patients (83.3% assessed as poor response) was observed (P = 0.501). Compared with patients with MSS tumours, patients with MSI-L tumours showed poor DFS (P = 0.018) with a hazard ratio (HR) of 2.839 (95% CI 1.131-7.124, P = 0.026) from multivariable cox regression analysis. However, this was not associated with OS (P = 0.063). MSI-L is an independent poor prognostic biomarker for the locally advanced gastric cancer treated with neoadjuvant chemotherapy. Further studies with larger sample sizes are needed for validation.

Original publication

DOI

10.1007/s00428-020-02878-6

Type

Journal article

Journal

Virchows Arch

Publication Date

02/2021

Volume

478

Pages

231 - 240

Keywords

Biomarker, Gastric cancer, MSI, Neoadjuvant chemotherapy, Prognosis, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Capecitabine, Chemotherapy, Adjuvant, Disease-Free Survival, Female, Gastrectomy, Humans, Lymph Node Excision, Male, Microsatellite Instability, Middle Aged, Neoadjuvant Therapy, Neoplasm Staging, Oxaloacetates, Prospective Studies, Risk Assessment, Risk Factors, Stomach Neoplasms, Time Factors