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<jats:title>Abstract</jats:title> <jats:p>The inherited bone marrow failure (BMF) syndromes are a rare and diverse group of genetic disorders that ultimately result in the loss of blood production. The molecular defects underlying many of these conditions have been elucidated, and great progress has been made toward understanding the normal function of these gene products. This review will focus on perhaps the most well-known and genetically heterogeneous BMF syndrome: Fanconi anemia. More specifically, this account will review the current state of our knowledge on why the bone marrow fails in this illness and what this might tell us about the maintenance of bone marrow function and hematopoiesis.</jats:p>

Original publication

DOI

10.1182/blood-2013-09-427740

Type

Journal article

Journal

Blood

Publisher

American Society of Hematology

Publication Date

02/01/2014

Volume

123

Pages

26 - 34