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OBJECTIVES: We sought to characterise the outcomes of patients with haematological malignancy and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in hospital in our regional network of 7 hospitals. METHODS: Consecutive hospitalised patients with haematological malignancy and SARS-CoV-2 infection were identified from 01/03/2020 to 06/05/2020. Outcomes were categorised as death, resolved or ongoing. The primary outcome was preliminary case fatality rate (pCFR), defined as the number of cases resulting in death as a proportion of all diagnosed cases. Analysis was primarily descriptive. RESULTS: 66 Patients were included, overall pCFR was 51.5%. Patients ≥ 70 years accounted for the majority of hospitalised cases (42, 63%) and fatalities (25, 74%). Mortality was similar between females (52%) and males (51%). Immunosuppressive or cytotoxic treatment within 3 months of the diagnosis of SARS-CoV-2 infection was associated with a significantly higher pCFR of 70%, compared with 28% in those not on active treatment (P = .0013, 2 proportions z test). CONCLUSIONS: Mortality rates in patients with haematological malignancy and SARS-CoV-2 infection in hospital are high supporting measures to minimise the risk of infection in this population.

Original publication

DOI

10.1111/ejh.13469

Type

Journal article

Journal

Eur J Haematol

Publication Date

10/2020

Volume

105

Pages

476 - 483

Keywords

SARS-CoV-2, haematological malignancy, Aged, Aged, 80 and over, Antineoplastic Agents, COVID-19, Cytotoxins, Female, Hematologic Neoplasms, Hospitalization, Humans, Immunosuppression, Male, Middle Aged, Pandemics, Prospective Studies, SARS-CoV-2, United Kingdom