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To investigate the association between dietary n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) and the degree and development of albuminuria in type 1 diabetes.We analyzed longitudinal data from 1,436 participants in the Diabetes Control and Complications Trial. We defined the average intake of eicosapentaenoic and docosahexaenoic acid from diet histories. Urinary albumin excretion rates (UAERs) were measured over 24 h; incident albuminuria was considered the first occurrence of an UAER >40 mg/24 h sustained for >or=1 year in normoalbuminuric individuals. RESULTS In a mean follow-up of 6.5 years, we observed a lower mean UAER (difference 22.7 mg/24 h [95% CI 1.6-43.8)]) in the top versus the bottom third of dietary n-3 LC-PUFAs, but we found no association with incident albuminuria.Dietary n-3 LC-PUFAs appear inversely associated with the degree but not with the incidence of albuminuria in type 1 diabetes. These findings require further investigation in prospective studies.

Original publication




Journal article


Diabetes care

Publication Date





1454 - 1456


Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.


Humans, Diabetic Nephropathies, Albuminuria, Diabetes Mellitus, Type 1, Fatty Acids, Omega-3, Docosahexaenoic Acids, Eicosapentaenoic Acid, Severity of Illness Index, Incidence, Risk Factors, Cohort Studies, Longitudinal Studies, Follow-Up Studies, Feeding Behavior, Adolescent, Adult, Female, Male, Randomized Controlled Trials as Topic, Young Adult