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Epidemiologists have found relationships between diabetes and cardiovascular disease and between the degree of hyperglycemia and cardiovascular disease. Clinical trials, however, have been less successful in providing convincing evidence to support changes in clinical care. Observational data from the DCCT and interventional data-notably, results related to metformin use from the UKPDS-support glucose lowering. Several ongoing studies in individuals with diabetes and "pre-diabetes" and in those with and without existing cardiovascular disease seek a definitive answer. If positive, these studies will justify even greater efforts toward glycemic control, and they may support blood glucose lowering in individuals without diabetes. © 2008 Current Medicine Group LLC.

Original publication




Journal article


Current Cardiovascular Risk Reports

Publication Date





66 - 71