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Total calculated uniform liver doses of up to 150 Gy were achieved using glass yttrium-90 microspheres administered via the hepatic artery and targeted to tumour using angiotensin II in seven patients with colorectal liver metastases. No toxicity was observed. Hepatic metastatic progression was delayed in six patients. Median survival was 11 months (range 5-25 + months).

Original publication

DOI

10.1016/0167-8140(92)90020-u

Type

Journal article

Journal

Radiother Oncol

Publication Date

10/1992

Volume

25

Pages

137 - 139

Keywords

Angiotensin II, Colorectal Neoplasms, Glass, Hepatic Artery, Humans, Injections, Intra-Arterial, Liver Neoplasms, Microspheres, Middle Aged, Radiotherapy Dosage, Yttrium Radioisotopes