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Population pharmacokinetic analysis of the anticancer agent epirubicin was carried out using the program NONMEM. Data were available from 36 patients aged 20-73 years, of whom 23 were women. All subjects exhibited normal liver and renal function. Epirubicin was given as a short-term i.v. infusion over the dose range of 25-100 mg/m2, and an average of 11 plasma samples/subject were taken for a period of up to 72 h after each dose. A Two compartment model was fitted to the data, characterised by the parameters clearance, volume of the central compartment, alpha and beta. Clearance was tested as a linear function of various demographic and/or biochemical features. A significant proportion of the variability in clearance could be attributed to sex, and also to age in women. For example, a 25-year-old man would display an average clearance of 95 l/h, whereas a 70-year-old woman would exhibit an average clearance of 64 l/h. Such differences in clearance might be important in the selection of epirubicin dose regimens.

Original publication

DOI

10.1007/bf00686009

Type

Journal article

Journal

Cancer Chemother Pharmacol

Publication Date

1992

Volume

29

Pages

391 - 395

Keywords

Adult, Aged, Aging, Breast Neoplasms, Chromatography, High Pressure Liquid, Epirubicin, Female, Hodgkin Disease, Humans, Linear Models, Male, Middle Aged, Models, Biological, Sarcoma, Sex Characteristics, Time Factors