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55 patients suffering from stage III or IV carcinoma of cervix were treated with two pulses of neo-adjuvant chemotherapy prior to radical radiotherapy. 51% (26/51) had a partial response. The initial response to chemotherapy is associated with significantly better long-term survival. The 3-year survival of chemotherapy responders is 62% against 21% for non-responders (P = 0.009 log-rank test). To detect possible differences in oncogene expression in biopsy specimens taken from responding and non-responding patients, paraffin-fixed material was immunocytochemically stained for the expression of the protein products of ras, c-myc and c-jun proto-oncogenes. The frequency of oncogene expression was ras 80.4%, c-myc 45.1% and c-jun 39.2%. There was no statistically significant association between oncogene expression, time to local recurrence or development of metastases or survival.

Original publication

DOI

10.1016/0959-8049(92)90053-5

Type

Journal article

Journal

Eur J Cancer

Publication Date

1992

Volume

28A

Pages

1615 - 1617

Keywords

Adult, Aged, Female, Gene Expression Regulation, Neoplastic, Genes, jun, Genes, myc, Genes, ras, Humans, Middle Aged, Prognosis, Retrospective Studies, Uterine Cervical Neoplasms