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Experimental data, particularly derived from tumour spheroids, indicate that drug penetration barriers may be an important determinant of cytotoxic drug efficacy, even in spheroids of only a few hundred microns in diameter. Clinically, tumour masses of this size would equate with those micrometastases which are the target of adjuvant chemotherapy in a wide range of tumour types. It is apparent, therefore, that even at this relatively early stage of the metastatic process, which ultimately proves to be fatal in many patients, measures aimed at improving drug penetration may prove to be crucial in improving the therapeutic efficacy of cytotoxic agents.

Original publication

DOI

10.1007/bf00296245

Type

Journal article

Journal

Cancer Chemother Pharmacol

Publication Date

1987

Volume

19

Pages

1 - 5

Keywords

Animals, Antibiotics, Antineoplastic, Biological Availability, Biological Transport, Cells, Cultured, Cricetinae, Cricetulus, Fibroblasts, Humans, Naphthacenes, Neoplasm Metastasis, Neoplasms