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PURPOSE: Congenital duodenal obstruction (CDO) is associated with trisomy 21 (T21), or Down's syndrome, in around a third of infants. The aim of this study was to explore the impact of T21 on the epidemiology, management, and outcomes of infants with CDO. METHODS: Data were prospectively collected from specialist neonatal surgical centres in the United Kingdom over a 12 month period from March 2016 using established population-based methodology for all babies with CDO. Infants with T21 were compared to those without any chromosomal anomaly. RESULTS: Of 102 infants with CDO that underwent operative repair, T21 was present in 33 [32% (95% CI 23-41%)] babies. Cardiac anomalies were more common in those with T21 compared to those without a chromosomal anomaly (91 vs 17%, p 

Original publication




Journal article


Pediatr Surg Int

Publication Date





477 - 483


Congenital cardiac disease, Down syndrome, Duodenal atresia, Duodenal stenosis, Trisomy 21, Abnormalities, Multiple, Digestive System Abnormalities, Digestive System Surgical Procedures, Down Syndrome, Duodenal Obstruction, Female, Humans, Incidence, Infant, Newborn, Male, Reoperation, Retrospective Studies, United Kingdom