Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The inter-differentiation between cell states promotes cancer cell survival under stress and fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience but its quantification is confounded by genetic heterogeneity. Here we show that NGH in serous ovarian cancer (SOC) can be accurately measured when informed by the molecular signatures of the normal fallopian tube epithelium (FTE) cells, the cells of origin of SOC. Surveying the transcriptomes of ∼6,000 FTE cells, predominantly from non-ovarian cancer patients, identified 6 FTE subtypes. We used subtype signatures to deconvolute SOC expression data and found substantial intra-tumor NGH. Importantly, NGH-based stratification of ∼1,700 tumors robustly correlated with survival. Our findings lay the foundation for accurate prognostic and therapeutic stratification of SOC.

Original publication




Journal article


Cancer Cell

Publication Date





226 - 242.e7


fallopian tube, non-genetic heterogeneity, ovarian cancer, single-cell RNA sequencing, Cystadenocarcinoma, Serous, Epithelial Cells, Epithelium, Fallopian Tube Neoplasms, Fallopian Tubes, Female, Gene Expression Regulation, Neoplastic, Genetic Heterogeneity, Humans, Ovarian Neoplasms