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The heart responds to sustained insults such as ischaemia and pressure overload with a dynamic remodelling process that ultimately leads to heart failure. This chronic response involving interaction of multiple organ systems necessitates the use of in vivo models, and the rat has a strong track record of translational research in this field. This review will discuss the common surgical models of myocardial infarction and aortic constriction in rats, and their increasing use in mice. © 2006 Elsevier Ltd. All rights reserved.

Original publication




Journal article


Drug Discovery Today: Disease Models

Publication Date





283 - 290