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Obesity is an important risk factor for the development of type 2 diabetes. The increasing incidence of obesity accounts in large part for the emergence of type 2 diabetes. Drug treatment of hyperglycaemia and hypertension lowers the risk of diabetic complications, but many of these treatments, including sulphonylureas, insulin and beta-blockers, are associated with weight gain. There is increasing evidence that obesity may be an independent risk factor for complications in both type 2 and type 1 diabetes. Therapies to lower body weight will undoubtedly have a role in the treatment of diabetes to potentially avert weight gain associated with anti-diabetic therapies, to lower glycaemia, and possibly even to lower the risk of diabetic complications. However, many questions remain to be answered.

Original publication




Conference paper

Publication Date



26 Suppl 4


S11 - S14


Adult, Aged, Diabetes Mellitus, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Middle Aged, Obesity, Risk Factors, Weight Gain, Weight Loss