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BACKGROUND: P-selectin (PS) is a marker of platelet activation measured on the platelet surface as platelet PS (pPS) or in serum as soluble PS (sPS). Controversy remains over the exact relationship between sPS, pPS, and other markers such as spontaneous platelet aggregation (SPA). OBJECTIVE: To investigate correlations between pPS, sPS, and SPA in patients with peripheral arterial disease. METHODS: SPA, pPS, and sPS levels were measured in venous blood sampled from patients following intermittent claudication (n = 18) or an acute stroke (n = 18). RESULTS: SPA and sPS correlated significantly in the claudicants (Pearson correlation coefficient, r = 0.661; P = .0020) and stroke patients (r = 0.514; P = .020). No significant correlation was identified between pPS and SPA, or sPS and pPS. CONCLUSIONS: The 2 methods of assessing PS are not comparable. Although pPS is accepted as a platelet activation marker, sPS may be a better indicator of aggregation represented by SPA.

Original publication

DOI

10.1177/1076029607305915

Type

Journal article

Journal

Clin Appl Thromb Hemost

Publication Date

04/2008

Volume

14

Pages

227 - 233

Keywords

Aged, Aged, 80 and over, Blood Platelets, Brain Ischemia, Female, Humans, Intermittent Claudication, Male, Middle Aged, P-Selectin, Pilot Projects, Platelet Activation, Platelet Aggregation, Stroke