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© 2019, Springer Nature Switzerland AG. Left ventricular function and morphology have been shown to be important factors in clinical and pre-clinical cardiovascular disease. In this paper we used atlas-based techniques to capture the full extent of morphological changes at end-diastole, end-systole and in a coupled functional atlas for 4547 UK Biobank participants. The morphological differences between participants with risk factors for cardiovascular disease were tested using a logistic regression model. The result was compared to a model built from traditional mass and volume measures, and the strength of associations were tested using a Delong’s test. Atlas based models had stronger associations with risk factors than mass and volume parameters in most risk factors. The functional atlas showed better performance than the separate end-diastole and end-systole atlases.

Original publication




Conference paper

Publication Date



11504 LNCS


304 - 312