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We present a high resolution radiation hybrid map of human chromosome 11 using 506 sequence tagged sites (STSs) scored on a panel of 86 radiation hybrids. The 506 STSs fall into 299 unique positions (average resolution of about 480 kilobases (kb)) that span the whole chromosome. A subset of 260 STSs (143 positions) form a framework map that has a resolution of approximately 1 megabase between adjacent positions and is ordered with odds of at least 1,000:1. The centromere was clearly defined with pericentric markers unambiguously assigned to the short or long arm. The map contains most genes (125) and expressed sequence tags (26) currently assigned to chromosome 11 and more than half of the STSs are polymorphic microsatellite loci. These markers and the map can be used for high resolution physical and genetic mapping.

Original publication

DOI

10.1038/ng0994-70

Type

Journal article

Journal

Nature genetics

Publication Date

09/1994

Volume

8

Pages

70 - 76

Addresses

INSERM U358, Paris, France.

Keywords

Chromosomes, Human, Pair 11, Centromere, Animals, Radiation Chimera, Humans, Genetic Markers, Chromosome Mapping, Sequence Tagged Sites, Cricetinae