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Our understanding of the pathogenesis of atopic dermatitis has been dramatically enhanced following the identification of the association with loss of function mutations in filaggrin, an epidermal protein thought to be important for cutaneous barrier integrity. However, it has also emerged that Th2 cytokines can influence barrier function, including through modulation of the expression of filaggrin, other structural proteins and peptides important for microbial barrier function. A picture is developing of a complex interplay between epidermal and non-epidermal susceptibilities that contribute to disease. Understanding the key components involved will be important for the identification of new approaches to treatment.

Original publication

DOI

10.1111/j.1365-2222.2008.03146.x

Type

Journal article

Journal

Clin Exp Allergy

Publication Date

03/2009

Volume

39

Pages

310 - 316

Keywords

Allergens, Animals, Communicable Diseases, Cytokines, Dermatitis, Atopic, Epidermis, Humans, Intermediate Filament Proteins, Permeability, T-Lymphocytes