BSc (Hons), DPhil
Postdoctoral Research Scientist
I am a postdoctoral research fellow in Prof Keith Channon's laboratory in the Division of Cardiovascular Medicine. I completed my DPhil in 2014 in which I studied the role of endothelial cell Gch1 and tetrahydrobiopterin (BH4) biosynthesis in vascular function and blood pressure regulation. I am currently investigating the role of endothelial cell BH4-dependent NOS regulation in vascular adaptations and blood pressure regulation in normal pregnancy using a novel mouse model of endothelial cell BH4 deficiency (endothelial cell-targeted Gch1 knockout mouse).
Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia-reperfusion injury.
Chu SM. et al, (2023), Exp Physiol, 108, 874 - 890
PHACTR1 modulates vascular compliance but not endothelial function: a translational study.
Wood A. et al, (2023), Cardiovasc Res, 119, 599 - 610
Endothelial cell vasodilator dysfunction mediates progressive pregnancy-induced hypertension in endothelial cell tetrahydrobiopterin deficient mice.
Chuaiphichai S. et al, (2023), Vascul Pharmacol, 150
Endothelial Cell-Specific Roles for Tetrahydrobiopterin in Myocardial Function, Cardiac Hypertrophy and Response to Myocardial Ischemia-Reperfusion Injury.
Chuaiphichai S. et al, (2023), Am J Physiol Heart Circ Physiol
Deletion of tetrahydrobiopterin synthesis in cardiomyocytes causes downregulation of fatty acid metabolism whilst protected against cardiac ischemia reperfusion injury
Chu S. et al, (2022), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 173, S125 - S125