Publications — Radcliffe Department of Medicine

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Novel Role of 5-Methyl-(6S)-Tetrahydrofolate in Mediating Endothelial Cell Tetrahydrobiopterin in Pregnancy and Implications for Gestational Hypertension.

Dickinson Y. et al, (2024), Hypertension

Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia-reperfusion injury.

Chu SM. et al, (2023), Exp Physiol, 108, 874 - 890

Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury.

Chuaiphichai S. et al, (2023), Am J Physiol Heart Circ Physiol, 324, H430 - H442

PHACTR1 modulates vascular compliance but not endothelial function: a translational study.

Wood A. et al, (2023), Cardiovasc Res, 119, 599 - 610

Endothelial cell vasodilator dysfunction mediates progressive pregnancy-induced hypertension in endothelial cell tetrahydrobiopterin deficient mice.

Chuaiphichai S. et al, (2023), Vascul Pharmacol, 150

Deletion of tetrahydrobiopterin synthesis in cardiomyocytes causes downregulation of fatty acid metabolism whilst protected against cardiac ischemia reperfusion injury

Chu S. et al, (2022), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 173, S125 - S125

Effects of canagliflozin on human myocardial redox signalling: clinical implications.

Kondo H. et al, (2021), Eur Heart J, 42, 4947 - 4960

Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth.

Chuaiphichai S. et al, (2021), Hypertension

Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With Cardiovascular Disease.

Akawi N. et al, (2021), J Am Coll Cardiol, 77, 2494 - 2513

BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes.

Carnicer R. et al, (2021), Circ Res, 128, 585 - 601

A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.

Douglas G. et al, (2020), Cardiovasc Res, 116, 1863 - 1874

Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology.

Bailey JD. et al, (2020), Nitric Oxide, 100-101, 17 - 29

Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition.

Akoumianakis I. et al, (2020), Sci Transl Med, 12

Direct effects of canagliflozin on human myocardial redox signalling: a novel role for SGLT1 inhibition

Kondo H. et al, (2020), EUROPEAN HEART JOURNAL, 41, 3351 - 3351

Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.

Akoumianakis I. et al, (2019), Sci Transl Med, 11

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.

Bailey JD. et al, (2019), Cell Rep, 28, 218 - 230.e7

Novel direct effects of SGLT2 inhibitor, Canagliflozin, on myocardial redox state in humans

Kondo H. et al, (2019), EUROPEAN HEART JOURNAL, 40, 3872 - 3872

Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control.

Patel J. et al, (2018), Vascul Pharmacol, 108, 15 - 22

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.

Douglas G. et al, (2018), Cardiovasc Res, 114, 1385 - 1399

Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.

Chuaiphichai S. et al, (2018), Hypertension, 72, 128 - 138

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