Contact information
Research groups
DPhil research opportunity
J. Ross Chapman
Ph.D
Associate Professor, CRUK CDF, Lister Fellow & EMBO Young Investigator
- Principal Investigator - Genome Integrity Group
Genome stability and DNA repair mechanisms in cancer and genome diversification
The accurate repair of DNA breaks is fundamental for protecting our genomes against cancer-causing mutations, however, the B and T lymphocytes of our immune systems deliberately induce and repair DNA breaks in a mutagenic fashion in order to adapt and diversify antigen receptor molecules. My group is interested in how cells and different tissues strike an appropriate equilibrium between accurate and mutagenic DNA repair mechanisms, so that we can understand why faults in this regulation lead to cancer, and devise innovative strategies to exploit these faults in cancer therapies.
Recent publications
-
Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer
Journal article
CHAPMAN J. et al, (2020), Nature
-
Journal article
Becker JR. et al, (2020)
-
Journal article
Anzilotti C. et al, (2019), Nat Immunol, 20, 350 - 361
-
Journal article
Nakamura K. et al, (2019), Nat Cell Biol, 21, 311 - 318
-
Journal article
Nakamura K. et al, (2019), NATURE CELL BIOLOGY, 21, 311 - +
-
Journal article
Becker JR. et al, (2018), Nat Commun, 9
-
Journal article
Ghezraoui H. et al, (2018), Nature, 560, 122 - 127
-
Journal article
Botuyan MV. et al, (2018), Nat Struct Mol Biol, 25, 591 - 600
-
Journal article
Barazas M. et al, (2018), Cell Rep, 23, 2107 - 2118
-
Journal article
Altemose N. et al, (2017), Elife, 6