Contact information
Research groups
DPhil research opportunity
J. Ross Chapman
Ph.D
Associate Professor, CRUK CDF, Lister Fellow & EMBO Young Investigator
- Principal Investigator - Genome Integrity Group
Genome stability and DNA repair mechanisms in cancer and genome diversification
The accurate repair of DNA breaks is fundamental for protecting our genomes against cancer-causing mutations, however, the B and T lymphocytes of our immune systems deliberately induce and repair DNA breaks in a mutagenic fashion in order to adapt and diversify antigen receptor molecules. My group is interested in how cells and different tissues strike an appropriate equilibrium between accurate and mutagenic DNA repair mechanisms, so that we can understand why faults in this regulation lead to cancer, and devise innovative strategies to exploit these faults in cancer therapies.
Recent publications
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Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer
Journal article
CHAPMAN J. et al, (2020), Nature
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BARD1 links histone H2A Lysine-15 ubiquitination to initiation of BRCA1-dependent homologous recombination
Journal article
Becker JR. et al, (2020)
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An essential role for the Zn2+ transporter ZIP7 in B cell development.
Journal article
Anzilotti C. et al, (2019), Nat Immunol, 20, 350 - 361
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H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.
Journal article
Nakamura K. et al, (2019), Nat Cell Biol, 21, 311 - 318
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H4K20meO recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids
Journal article
Nakamura K. et al, (2019), NATURE CELL BIOLOGY, 21, 311 - +
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The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity.
Journal article
Becker JR. et al, (2018), Nat Commun, 9
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53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.
Journal article
Ghezraoui H. et al, (2018), Nature, 560, 122 - 127
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Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.
Journal article
Botuyan MV. et al, (2018), Nat Struct Mol Biol, 25, 591 - 600
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The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.
Journal article
Barazas M. et al, (2018), Cell Rep, 23, 2107 - 2118
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A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis.
Journal article
Altemose N. et al, (2017), Elife, 6