Publications — Radcliffe Department of Medicine

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BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution.

Tsukada K. et al, (2024), Mol Cell

Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice

KING A. et al, (2023)

Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution.

Rodriguez-Meira A. et al, (2023), Nat Genet, 55, 1531 - 1541

53BP1-shieldin-dependent DSB processing in BRCA1-deficient cells requires CST-Polα-primase fill-in synthesis.

Mirman Z. et al, (2022), Nat Cell Biol, 24, 51 - 61

BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination.

Becker JR. et al, (2021), Nature, 596, 433 - 437

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.

Hewitt G. et al, (2021), Mol Cell, 81, 767 - 783.e11

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

Yeow ZY. et al, (2020), Nature, 585, 447 - 452

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining.

Francica P. et al, (2020), Cell Rep, 32

BARD1 links histone H2A Lysine-15 ubiquitination to initiation of BRCA1-dependent homologous recombination

Becker JR. et al, (2020)

An essential role for the Zn2+ transporter ZIP7 in B cell development.

Anzilotti C. et al, (2019), Nat Immunol, 20, 350 - 361

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

Nakamura K. et al, (2019), Nat Cell Biol, 21, 311 - 318

H4K20meO recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids

Nakamura K. et al, (2019), NATURE CELL BIOLOGY, 21, 311 - +

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity.

Becker JR. et al, (2018), Nat Commun, 9

53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.

Ghezraoui H. et al, (2018), Nature, 560, 122 - 127

Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.

Botuyan MV. et al, (2018), Nat Struct Mol Biol, 25, 591 - 600

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.

Barazas M. et al, (2018), Cell Rep, 23, 2107 - 2118

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis.

Altemose N. et al, (2017), Elife, 6

Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility.

Wright DJ. et al, (2017), Nat Genet, 49, 674 - 679

A 53BP1 integrates DNA repair and p53-dependent cell fate decisions via distinct mechanisms

Cuella-Martin R. et al, (2017), MOLECULAR CANCER RESEARCH, 15

53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms.

Cuella-Martin R. et al, (2016), Mol Cell, 64, 51 - 64

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