Contact information
+44 (0) 1865 572898
Colleges
Ileana Badi
PhD
Postdoctoral Researcher
My principal research interests lie in understanding the cellular and molecular mechanisms leading to cardiovascular disease. I obtained my Ph.D. in 2008 at the University of Insubria (Italy), where I studied the role of the transcription factor Ankrd1 in the pathogenesis of the rare congenital heart disease Total Anomalous Pulmonary Venous Return (TAPVR). Hence, I decided to deepen my knowledge on the transcriptional control of cardiac development in Professor Vincent M. Christoffels’s lab at the University of Amsterdam. There, I studied the transcriptional regulation of Tbx3 gene that encodes a transcription factor important for the conduction system and arterial pole morphogenesis. At this point I felt the need to move towards more translational studies; thus, I spent six years at the Centro Cardiologico Monzino, in Milan, where I focused my attention on the role of miR-34a in vascular “inflammaging” and vascular calcification, as this microRNA could be a promising therapeutic target for cardiovascular disease. In June 2018 I joined The Oxford Translational Cardiovascular Research Group, that superbly combines basic science and clinical research. Here, I am keen on studying how the cross-talk between adipose tissue and the cardiovascular system can affect cardiovascular disease.
Key publications
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Brown Adipose Tissue and the Take (12,13-di)HOME Message to the Heart.
Journal article
Badi I. and Antoniades C., (2021), Circulation, 143, 160 - 162
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Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.
Journal article
Akoumianakis I. et al, (2019), Sci Transl Med, 11
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Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition.
Journal article
Akoumianakis I. et al, (2020), Sci Transl Med, 12
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miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase).
Journal article
Badi I. et al, (2018), Arterioscler Thromb Vasc Biol, 38, 2079 - 2090
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MicroRNA-34a Induces Vascular Smooth Muscle Cells Senescence by SIRT1 Downregulation and Promotes the Expression of Age-Associated Pro-inflammatory Secretory Factors.
Journal article
Badi I. et al, (2015), J Gerontol A Biol Sci Med Sci, 70, 1304 - 1311
Recent publications
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Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19.
Journal article
Kotanidis CP. et al, (2022), Lancet Digit Health
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Editorial: Exploring the Crosstalk Between Adipose Tissue and the Cardiovascular System
Journal article
Badi I. et al, (2022), Frontiers in Cell and Developmental Biology, 10
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ADIPOSE TISSUE DERIVED CERAMIDES REGULATE MYOCARDIAL REDOX STATE AND PREDICT CARDIOVASCULAR OUTCOMES
Conference paper
Polkinghorne M. et al, (2022), HEART, 108, A143 - A144
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Effects of canagliflozin on human myocardial redox signalling: clinical implications.
Journal article
Kondo H. et al, (2021), Eur Heart J, 42, 4947 - 4960
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A Novel Human Arterial Transcriptomic Signature Associated With Major Adverse Cardiovascular Events and Oxidative Stress
Conference paper
Kotanidis C. et al, (2021), CIRCULATION, 144