Contact information
+44 (0) 1865 572898
Ileana Badi
PhD
Senior Postdoctoral Researcher
My principal research interests lie in understanding the cellular and molecular mechanisms leading to cardiovascular disease. I obtained my Ph.D. in 2008 at the University of Insubria (Italy), where I studied the role of the transcription factor Ankrd1 in the pathogenesis of the rare congenital heart disease Total Anomalous Pulmonary Venous Return (TAPVR). Hence, I decided to deepen my knowledge on the transcriptional control of cardiac development in Professor Vincent M. Christoffels’s lab at the University of Amsterdam. There, I studied the transcriptional regulation of Tbx3 gene that encodes a transcription factor important for the conduction system and arterial pole morphogenesis. At this point I felt the need to move towards more translational studies; thus, I spent six years at the Centro Cardiologico Monzino, in Milan, where I focused my attention on the role of miR-34a in vascular “inflammaging” and vascular calcification, as this microRNA could be a promising therapeutic target for cardiovascular disease. In June 2018 I joined The Oxford Translational Cardiovascular Research Group, that superbly combines basic science and clinical research. Here, I am keen on studying how the cross-talk between adipose tissue and the cardiovascular system can affect cardiovascular disease.
Key publications
-
Role of Human Epicardial Adipose Tissue-Derived miR-92a-3p in Myocardial Redox State.
Journal article
Carena MC. et al, (2023), J Am Coll Cardiol, 82, 317 - 332
-
Effects of canagliflozin on human myocardial redox signalling: clinical implications.
Journal article
Kondo H. et al, (2021), Eur Heart J, 42, 4947 - 4960
-
Brown Adipose Tissue and the Take (12,13-di)HOME Message to the Heart.
Journal article
Badi I. and Antoniades C., (2021), Circulation, 143, 160 - 162
-
Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition.
Journal article
Akoumianakis I. et al, (2020), Sci Transl Med, 12
-
miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase).
Journal article
Badi I. et al, (2018), Arterioscler Thromb Vasc Biol, 38, 2079 - 2090
Recent publications
-
Role of Human Epicardial Adipose Tissue-Derived miR-92a-3p in Myocardial Redox State.
Journal article
Carena MC. et al, (2023), J Am Coll Cardiol, 82, 317 - 332
-
Genetic variability of lipoprotein(a) controls vascular inflammation/redox signalling and predicts adverse cardiovascular outcomes in coronary artery disease N.
Journal article
Polkinghorne MD. et al, (2023), EUROPEAN HEART JOURNAL, 44
-
Human epicardial adipose tissue-secreted miR-92a-3p regulates myocardial redox state via paracrine signalling: implications for cardiovascular clinical outcomes
Journal article
Badi I. et al, (2023), EUROPEAN HEART JOURNAL, 44
-
Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19.
Journal article
Kotanidis CP. et al, (2022), Lancet Digit Health, 4, e705 - e716
-
Editorial: Exploring the Crosstalk Between Adipose Tissue and the Cardiovascular System
Journal article
Badi I. et al, (2022), Frontiers in Cell and Developmental Biology, 10
