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The first participant has completed initial study activities and is now randomised to one of the trial’s arms.

A photograph of the chief investigator and research nurses for the LEGEND-D trial © OCDEM
LEGEND-D clinical site research team

The LEGEND-D trial aims to find ways to prevent low blood sugar levels (hypoglycaemia) in type 1 diabetes. It will use  oral diabetic medications, which are normally used to treat type 2 diabetes, in people with type 1 diabetes. Researchers will find out whether administering these medications at smaller doses than normally prescribed could help prevent hypoglycaemia. We will recruit 20 participants with type 1 diabetes and 10 participants without diabetes.

If you are interested in taking part in this trial and wish to know more, please contact the research team at or