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Functional genomics of type 2 diabetes

Gloyn Group: Functional Genomics of Type 2 diabetes

Oxford Centre for Diabetes, Endocrinology and Metabolism

Our mission is to improve understanding of pancreatic islet cell dysfunction in type 2 diabetes using human genetics as a tool to uncover causal disease mechanisms and shed light on potential targets for therapeutic development.

Diabetes trials unit

Holman Group: Diabetes Trials Unit

Oxford Centre for Diabetes, Endocrinology and Metabolism

The Diabetes Trials Unit (DTU) is a fully registered UKCRC Clinical Trials Unit, specialising in performing national and multinational clinical trials related to diabetes.

Metabolic research group

Karpe, Hodson and Christodoulides Group: Metabolic Research Group

Oxford Centre for Diabetes, Endocrinology and Metabolism

We apply an integrated approach to human metabolic disease which involves genetic, genomic, cell biology and whole body metabolic studies to understand the pathogenesis of the complications of obesity such as fatty liver disease, type 2 diabetes and cardiovascular disease.

Type 2 diabetes genetics and genomics

McCarthy Group: Type 2 Diabetes Genetics and Genomics

Oxford Centre for Diabetes, Endocrinology and Metabolism

We aim to understand why some people are more likely than others to develop type 2 diabetes and related conditions such as obesity. We combine genetic, molecular and clinical data to find clues to disease mechanisms that will lead to more effective strategies for prevention and treatment.

Rorsman group

Rorsman Group

Oxford Centre for Diabetes, Endocrinology and Metabolism

We study cellular physiology of pancreatic islets – the small organs that regulate the whole-body sugar levels. Our work will help to find new treatments for diabetes – a disease that is characterised by uncontrolled blood sugar.

Thakker group academic endocrine unit

Thakker Group: Academic Endocrine Unit

Oxford Centre for Diabetes, Endocrinology and Metabolism

We investigate the genetic, molecular and physiological basis of endocrine disorders that affect calcium homeostasis, and endocrine tumour development. By identifying and understanding the underlying mechanisms, we aim to establish better diagnostic methods and develop novel targeted therapies for these disorders to improve patient care.

Metabolism and steroid hormone biology tomlinson

Tomlinson Group: Metabolism and Steroid Hormone Biology

Oxford Centre for Diabetes, Endocrinology and Metabolism

We work to understand how hormones regulate metabolic health in liver, fat and skeletal muscle. Our research has helped to define the role of ‘pre-receptor’ hormone metabolism in the pathogenesis of metabolic disease and has contributed to the development of novel interventions with the ultimate aim of improving patient care.

Ray group

Ray Group

We work on circadian rhythms, and nuclear receptors applied to both inflammation and energy metabolism. Our models range from cells to human populations.