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Published papers

  • Li W, Mandeville ET, Duran-Laforet V, Fukuda N, Yu Z, Zheng Y, Held A, Park JH, Nakano T, Takana M, Shi J, Esposito E, Niu W, Xing C, Hayakawa K, Lizasoain I, van Leyen K, Ji X, Wainger B, Moro M, Lo EH. Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke. Nat Commun 2022; 13:7812.


  • Klerman EB, Brager A, Carskadon MA, Depner CM, Foster R, Goel N, Harrington M, Holloway PM, Knauert MP, LeBourgeois MK, Lipton J, Merrow M, Montagnese S, Ning M, Ray D, Scheer FAJL, Shea SA, Skene DJ, Spies C, Staels B, St-Onge M, Tiedt S, Zee PC, Burgess HJ. Keeping an eye on circadian time in clinical research and medicine. Clin Transl Med. 2022 Dec;12(12):e1131


  • Esposito E, Zhang F, Park JH, Mandeville ET, Li W, Cuartero MI, Lizasoaín I, Moro MA, Lo EH. Diurnal Differences in Immune Response in Brain, Blood and Spleen After Focal Cerebral Ischemia in Mice. Stroke. 2022 Nov 2.


  • Tiedt S, Buchan AM, Dichgans M, Lizasoain I, Moro MA, Lo EH. The neurovascular unit and systemic biology in stroke - implications for translation and treatment. Nat Rev Neurol. 2022 Oct;18(10):597-612.


  • Mandeville ET, Li W, Quinto-Alemany D, Zhang F, Esposito E, Nakano T, Mandeville JB, Lee J, Park JH, Arai K, Waeber C, Lizasoain I, Moro MÁ, Lo EH. Fingolimod Does Not Reduce Infarction After Focal Cerebral Ischemia in Mice During Active or Inactive Circadian Phases. Stroke. 2022 Oct 12.


  • Walther J, Kirsch EM, Hellwig L, Schmerbeck SS, Holloway PM, Buchan AM, Mergenthaler P. Reinventing the Penumbra - the Emerging Clockwork of a Multi-modal Mechanistic Paradigm. Transl Stroke Res. 2022 Oct 11.


  • Ryu WS, Hong KS, Jeong SW, Park JE, Kim BJ, Kim JT, Lee KB, Park TH, Park SS, Park JM, Kang K, Cho YJ, Park HK, Lee BC, Yu KH, Oh MS, Lee SJ, Kim JG, Cha JK, Kim DH, Lee J, Han MK, Park MS, Choi KH, Lee J, Saver JL, Lo EH, Bae HJ, Kim DE. Association of ischemic stroke onset time with presenting severity, acute progression, and long-term outcome: A cohort study. PLoS Med. 4;19(2) (2022)  10.1371/journal.pmed.1003910


  • Reidler P, Brehm A, Sporns PB, Burbano VG, Stueckelschweiger L, Broocks G, Liebig T, Psychogios MN, Ricke J, Dimitriadis K, Dichgans M, Kunz WG, Tiedt S. Circadian rhythm of ischaemic core progression in human stroke. J Neurol Neurosurg Psychiatry. (2021)


  • Lo EH, Albers GW, Dichgans M, Donnan G, Esposito E, Foster R, Howells DW, Huang YG, Ji X, Klerman EB, Lee S, Li W, Liebeskind DS, Lizasoain I, Mandeville ET, Moro MA, Ning M, Ray D, Sakadžić S, Saver JL, Scheer FAJL, Selim M, Tiedt S, Zhang F, Buchan AM. Circadian Biology and Stroke. Stroke. 52(6):2180-2190 (2021)


  • Esposito E, Li W, T Mandeville E, Park JH, Şencan I, Guo S, Shi J, Lan J, Lee J, Hayakawa K, Sakadžić S, Ji X, Lo EH.. Potential circadian effects on translational failure for neuroprotection. Nature 582, 395–398 (2020).


In Press


  • Li W, Shi J, Z Yu, Huang L, Ji X, Lo EH. The iron-handling receptor Slc22a17 as a potential blood-brain barrier target after stroke. Stroke (submitted).

  • Klerman EB, Kramer A, Zee PC. From bench to bedside and back again: translating circadian science to medicine. J Biol Rhythms 2022; Epub ahead of print.