Publications — Radcliffe Department of Medicine

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Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS.

Hertzog J. et al, (2022), EMBO J, 41

Fractional response analysis reveals logarithmic cytokine responses in cellular populations

Nienałtowski K. et al, (2021), Nature Communications, 12

Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.

Tang Q. et al, (2021), Immunity, 54, 1961 - 1975.e5

Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype.

Fraser E. et al, (2021), Front Immunol, 12

Fractional response analysis reveals logarithmic cytokine responses in cellular populations

Nienałtowski K. et al, (2020)

Recognition of Z-RNA by ADAR1 limits interferon responses

Tang Q. et al, (2020)

A versatile mouse model of COVID-19.

Borrmann H. and Rigby RE., (2020), Nat Rev Immunol, 20

SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.

Davenne T. et al, (2020), Cell Rep, 31

Varicella-Zoster Virus ORF9 Is an Antagonist of the DNA Sensor cGAS

Hertzog J. et al, (2020)

Deoxyguanosine is a TLR7 agonist.

Davenne T. et al, (2020), Eur J Immunol, 50, 56 - 62

PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection.

Rigby RE. et al, (2019), Sci Rep, 9

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.

Hansen AL. et al, (2018), Proc Natl Acad Sci U S A, 115, E7768 - E7775

Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.

Hertzog J. et al, (2018), Eur J Immunol, 48, 1120 - 1136

Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.

Mackenzie KJ. et al, (2016), EMBO J, 35, 831 - 844

RNA degradation in antiviral immunity and autoimmunity

Rigby RE. and Rehwinkel J., (2015), Trends in Immunology, 36, 179 - 188

RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.

Rigby RE. et al, (2014), EMBO J, 33, 542 - 558

SAMHD1-dependent retroviral control and escape in mice

Rehwinkel J. et al, (2013), RETROVIROLOGY, 10, S28 - S28

SAMHD1-dependent retroviral control and escape in mice

Rehwinkel J. et al, (2013), EMBO Journal, 32, 2454 - 2462

SAMHD1-dependent retroviral control and escape in mice

Rehwinkel J. et al, (2013), Retrovirology, 10, P70 - P70

Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

Reijns MAM. et al, (2012), Cell, 149, 1008 - 1022

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