Publications — Radcliffe Department of Medicine

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Dissociation between liver fat content and fasting metabolic markers of selective hepatic insulin resistance in humans

Westcott F. et al, (2024), European Journal of Endocrinology (EJE)

Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT.

Hengist A. et al, (2024), Cell Rep Med, 5

Elevations in plasma glucagon are associated with reduced insulin clearance after ingestion of a mixed-macronutrient meal in people with and without type 2 diabetes.

Smith K. et al, (2024), Diabetologia

Greater oxidation of dietary linoleate compared to palmitate in humans following an acute high-carbohydrate diet

Srnic N. et al, (2024), Clinical Nutrition

LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells

Hodson D., (2024), Cell Reports

Circadian regulation of liver metabolism: experimental approaches in human, rodent, and cellular models.

Daniels LJ. et al, (2023), Am J Physiol Cell Physiol, 325, C1158 - C1177

Hepatic fatty acid and glucose handling in metabolic disease: Potential impact on cardiovascular disease risk

Westcott F. et al, (2023), Atherosclerosis, 117237 - 117237

Hepatocyte mARC1 promotes fatty liver disease

Lewis LC. et al, (2023), JHEP Reports, 5

MLX plays a key role in lipid and glucose metabolism in humans: evidence from in vitro and in vivo studies

NAGARAJAN S. et al, (2023), Metabolism: clinical and experimental

Detection and alterations of acetylcarnitine (AC) in human liver by 1 H MRS at 3T after supplementation with l-carnitine.

Savic D. et al, (2023), Magn Reson Med, 89, 1314 - 1322

Nutritional regulation of hepatic de novo lipogenesis in humans.

Cross E. et al, (2023), Curr Opin Clin Nutr Metab Care, 26, 65 - 71

11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial.

Othonos N. et al, (2023), Nat Commun, 14

An optimised protocol for the investigation of insulin signalling in a human cell culture model of adipogenesis.

Gamwell JM. et al, (2023), Adipocyte

NAFLD is a night-time disease driven by nocturnal hepatic, adipose, and skeletal muscle insulin resistance

Marjot T. et al, (2023), JOURNAL OF HEPATOLOGY, 78, S731 - S731

Determining the temporal, dose, and composition effects of nutritional substrates in an in vitro model of intrahepatocellular triglyceride accumulation.

Nagarajan SR. et al, (2022), Physiol Rep, 10

The PNPLA3 I148M variant increases intrahepatic lipolysis and beta oxidation and decreases de novo lipogenesis and hepatic mitochondrial function in vivo in humans

Luukkonen PK. et al, (2022), DIABETOLOGIA, 65, S76 - S76

Intrahepatic triglyceride content: influence of metabolic and genetics drivers.

Dearlove DJ. and Hodson L., (2022), Curr Opin Clin Nutr Metab Care, 25, 241 - 247

The PNPLA3 I148M variant increases intrahepatic lipolysis and beta oxidation and decreases de novo lipogenesis and hepatic mitochondrial function in humans

Luukkonen P. et al, (2022), JOURNAL OF HEPATOLOGY, 77, S690 - S691

Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents.

Hazlehurst JM. et al, (2022), Metabol Open, 14

The effects of endogenously- and exogenously-induced hyperketonemia on exercise performance and adaptation.

Dearlove DJ. et al, (2022), Physiol Rep, 10

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