Colleges
Research groups
Jack Tan
DPhil, BSc (Hons)
Senior Postdoctoral Scientist
I am a EPA Cephalosporin Early Research and Teaching Fellow at St Edmund Hall. I am currently working as a postdoctoral scientist in Alain Townsend lab at the Weatherall Institute of Molecular Medicine on developing a single cycle influenza vaccine (S-FLU) for clinical trials. Apart form that, I am trying to further understand the immune responses against influenza elicited by S-FLU in animal models and humans. We have also recently started developing vaccines and therapeutic antibodies for coronavirus (SARS-nCoV-2).
Recent publications
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Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection.
Journal article
Frost JN. et al, (2021), Med (N Y), 2, 164 - 179.e12
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A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses.
Journal article
Tan TK. et al, (2021), Nat Commun, 12
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Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.
Journal article
Huo J. et al, (2020), Nat Struct Mol Biol, 27
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Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation
Journal article
Rahikainen R. et al, (2020), Angewandte Chemie
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Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell-cell fusion.
Journal article
Thakur N. et al, (2020), J Gen Virol
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike.
Journal article
Huo J. et al, (2020), Cell Host Microbe, 28
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Overcoming Symmetry Mismatch in Vaccine Nanoassembly via Spontaneous Amidation.
Journal article
Howarth M. et al, (2020), Angew Chem Int Ed Engl