Contact information
+44 (0)1865 226829
Fax +44 (0)1865 740449
Laura Bourne
laura.bourne@cardiov.ox.ac.uk
Colleges
Saul Myerson
MB ChB, MD, FRCP, FESC
Associate Professor of Cardiovascular Medicine
- Consultant Cardiologist
My research focusses mainly on heart valve disease, in particular using cardiac imaging to identify patients at risk of future problems, and to understand mechanisms of disease. I also examine aortic disease to understand the causes and potential treatments. Some of my recent work included being able to predict which patients with leaky heart valves are likely to require surgery in the near future, by quantifying the amount of regurgitation (leak) across the valve using cardiovascular magnetic resonance imaging. This research enables advance planning with the patient, including performing earlier surgery, or for those with lower amounts of leak, a reduced frequency of follow up (saving patient time and healthcare resources). I use 4-dimensional blood flow imaging (3-D flow over time) with cardiovascular magnetic resonance to examine blood flow patterns within the heart and aorta. This has enabled my team to look at why the aorta dilates in some patients, and what changes in cardiac efficiency occur with differing anatomy. We plan to study these flow patterns in patients with congenital heart disease to understand why some are able to function better than others. My research also involves being principal investigator for the OxValve study, a large study of >4,000 people in Oxfordshire. Lastly, I conduct clinical trials of early valve surgery and of novel drugs to improve how well the heart muscle is able to cope with valve disease. I qualified from the University of Bristol and completed my training in London and Oxford. I am the valve sub-theme lead for the Oxford Biomedical Research Centre, and board member of the British Society for Cardiovascular Magnetic Resonance. In addition to >75 publications, I have edited three Oxford Handbooks.
Key publications
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Determination of Clinical Outcome in Mitral Regurgitation With Cardiovascular Magnetic Resonance Quantification.
Journal article
Myerson SG. et al, (2016), Circulation, 133, 2287 - 2296
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Large-scale community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people: the OxVALVE Population Cohort Study.
Journal article
d'Arcy JL. et al, (2016), Eur Heart J, 37, 3515 - 3522
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A prospective, double-blind, randomized controlled trial of the angiotensin-converting enzyme inhibitor Ramipril In Aortic Stenosis (RIAS trial).
Journal article
Bull S. et al, (2015), Eur Heart J Cardiovasc Imaging, 16, 834 - 841
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Aortic dilation in bicuspid aortic valve disease: flow pattern is a major contributor and differs with valve fusion type.
Journal article
Bissell MM. et al, (2013), Circ Cardiovasc Imaging, 6, 499 - 507
Recent publications
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Measurement of exhaled nitric oxide fails to predict left atrial pressure assessed by E/e ratio in elderly patients.
Journal article
Jones ST. et al, (2022), BJGP Open
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Artificial Intelligence for Contrast-free MRI: Scar Assessment in Myocardial Infarction Using Deep Learning-based Virtual Native Enhancement (VNE).
Journal article
Zhang Q. et al, (2022), Circulation
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B-Type Natriuretic Peptide at Admission Is a Predictor of All-Cause Mortality at One Year after the First Acute Episode of New-Onset Heart Failure with Preserved Ejection Fraction
Journal article
Ghilencea L-N. et al, (2022), Journal of Personalized Medicine, 12, 890 - 890
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United Kingdom standards for non-invasive cardiac imaging: recommendations from the Imaging Council of the British Cardiovascular Society
Journal article
Treibel TA. et al, (2022), Heart
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Association of Myocardial Fibrosis and Stroke Volume by Cardiovascular Magnetic Resonance in Patients With Severe Aortic Stenosis With Outcome After Valve Replacement: The British Society of Cardiovascular Magnetic Resonance AS700 Study.
Journal article
Thornton GD. et al, (2022), JAMA Cardiol
ORCID
0000-0001-5927-0230