DPhil, BSc (Hons)
Postdoctoral Research Scientist
Following the completion of my BSc in Pharmacology from the University of Southampton I joined the Gene Medicine Research Group to pursue an MRC Industrial CASE DPhil studentship collaborating with Oxford Biomedica. I Investigated different lentiviral vector pseudotypes for gene delivery to the lung using a range of in vitro, in vivo and ex vivo techniques. I established a human tissue collection under the university’s HTA licence allowing me to also evaluate the ability of different models to predict clinical translation.
Since confirming the use of a human receptor by the Sendai virus F/HN pseudotype my postdoctoral research has been focussed on the development of this platform for therapeutic applications. Last year I supervised a Cystic Fibrosis Trust studentship and I am currently investigating the potential to treat various surfactant protein deficiencies.
As a member of the Oxford A Research Ethics Committee I am also responsible for the review clinical trials on behalf of the UK Health Research Authority. Exploring ways to improve our approach to gene therapy applications, we are developing an online resource aimed at supporting lay members.
I am also passionate to engage and involve patient and public communities in the meaning and scope of current gene therapy research, as well as gain insight into existing values and perspectives. Using a Wellcome Trust Enriching Engagement award I even ran a stall at Glastonbury festival this year!
Reshaping consent so we might improve participant choice (II) – helping people decide
Davies H. et al, (2023), Research Ethics
Sendai F/HN pseudotyped lentiviral vector transduces human ciliated and non-ciliated airway cells using α 2,3 sialylated receptors
Munday RJ. et al, (2022), Molecular Therapy - Methods and Clinical Development, 26, 239 - 252
F/HN Pseudotyped Lentiviral Vector Uses Alpha 2,3 Sialylated N-Acetyllactosamine to Efficiently Transduce Human Airway Cells
Munday RJ. et al, (2022), MOLECULAR THERAPY, 30, 12 - 12
Oligomeric Aβ1-42 Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function
Lynn SA. et al, (2021), Cells, 10, 413 - 413
Lentiviral Vector Pseudotyped with Sendai Virus F and HN Proteins Uses Sialylated Glycan Receptors to Efficiently Target Human Airway Cells
Munday RJ. et al, (2020), MOLECULAR THERAPY, 28, 130 - 130