Parag Gajendragadkar

MA, MB BChir, MPhil, MRCP

Clinical Research Fellow & DPhil Student

As a clinician pursuing a DPhil in Professor Barbara Casadei's group, my work involves investigating the effects of Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) on cardiac repolarisation and arrhythmogenesis. Variations in non-coding regions within the gene coding for NOS1AP have been consistently found in human studies to be linked to measures of cardiac electrical activity (the QT interval) and risk of sudden cardiac death due to abnormal heart rhythms in a wide variety of populations.

My work aims to use a transgenic mouse overexpressing NOS1AP in the heart to investigate its effects on QT interval and inducibility of ventricular arrhythmias by a variety of techniques including in vivo arrhythmia induction, optical mapping, patch clamping and immunohistochemistry. We are also investigating these effects in human cardiac cells.

These investigations will elucidate the mechanisms by which NOS1AP and NOS1 alter myocardial repolarisation and excitability and further our understanding of the mechanisms of unexplained sudden cardiac death in otherwise healthy people beyond well characterised but rare single gene syndromes.

I completed my undergraduate and clinical training at Downing College, University of Cambridge and qualified in 2008. After doing Foundation Training in East Anglia, I was a Wellcome Trust funded Academic Clinical Fellow and completed an MPhil in Translational Medicine and Therapeutics from the University of Cambridge. I then became a Cardiology Registrar and after completing my core training have subspecialised in the field of Electrophysiology and Devices. I moved to the University of Oxford as a British Heart Foundation funded Clinical Research Training Fellow to pursue research as a DPhil student.

Recent Publications

Improved outcome and cost effectiveness in ablation of persistent atrial fibrillation under general anaesthetic.
Martin CA. et al, (2017), Europace
Applicability of a risk score for prediction of the long-term benefit of the implantable cardioverter defibrillator in patients receiving cardiac resynchronization therapy.
Barra S. et al, (2016), Europace, 18, 1187 - 1193
Flow rates through intravenous access devices: an in vitro study.
Khoyratty SI. et al, (2016), J Clin Anesth, 31, 101 - 105
Diagnostic accuracy of cardiothoracic ratio on admission chest radiography to detect left or right ventricular systolic dysfunction: a retrospective study.
Chana HS. et al, (2015), J R Soc Med, 108, 317 - 324
Wearable technology: using Google Glass as a teaching tool.
Knight HM. et al, (2015), BMJ Case Rep, 2015

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ORCID

0000-0003-3312-0183