Contact information
Research groups
Research groups
Matthew Gosden
Research Assistant
I currently work in the Hughes group on a Wellcome Trust Strategic Award grant looking to find SNPs that disrupt gene regulation and cause disease.
I work with a range of techniques, many of which utilise Next Generation Sequencing, to characterise the genetic landscape of cells. One such method is Capture C, a technique developed in the Hughes lab that takes a standard 3C library and pulls down a specified region of interest to gain a one vs all snapshot of that region.
On top of research, I am also involved in training collaborators and students in these techniques. As well as practical work I enjoy taking a proactive role in public engagement events.
Recent publications
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Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.
Journal article
Mettananda S. et al, (2017), Nat Commun, 8
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Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.
Journal article
Hanssen LLP. et al, (2017), Nat Cell Biol, 19, 952 - 961
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Functional characterisation ofcis-regulatory elements governing dynamicEomesexpression in the early mouse embryo.
Journal article
Simon CS. et al, (2017), Development, 144, 1249 - 1260