Matthew Gosden

Research Assistant

I currently work in the Hughes group on a Wellcome Trust Strategic Award grant looking to find SNPs that disrupt gene regulation and cause disease.

I work with a range of techniques, many of which utilise Next Generation Sequencing, to characterise the genetic landscape of cells. One such method is Capture C, a technique developed in the Hughes lab that takes a standard 3C library and pulls down a specified region of interest to gain a one vs all snapshot of that region.

On top of research, I am also involved in training collaborators and students in these techniques. As well as practical work I enjoy taking a proactive role in public engagement events.

Recent publications

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.
Journal article

Mettananda S. et al, (2017), Nat commun, 8
Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.
Journal article

Hanssen LLP. et al, (2017), Nat cell biol, 19, 952 - 961
Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo.
Journal article

Simon CS. et al, (2017), Development, 144, 1249 - 1260

More publications