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Mary-Anne Durin

DPhil student

In October 2020, I started as a DPhil student in the Chapman lab. 

My research focuses on the molecular mechanism of BRCA1-dependent 53BP1 exclusion and its role in double-strand break (DSB) repair pathway choice.

 

Prior to starting my DPhil, I completed my BSc in Biomedical Sciences at Brunel University London. During this time, I had a 12-month research-based placement at the Wellcome Centre for Human Genetics, Oxford. I was part of the Chromosome Dynamics Core group and gained extensive experience in cytogenetics and worked on numerous chromosome instability and genome integrity projects. This increasingly developed my interest in DNA DSB repair mechanisms and of genome instability in cancer.

Publications

  • Mandriota SJ, Tenan M, Nicolle A, Jankowska JD, Ferrari P, Tille JC, Durin MA, Green CM, Tabruyn S, Moralli D, Sappino AP. Genomic Instability Is an Early Event in Aluminium-Induced Tumorigenesis. Int J Mol Sci. 2020 Dec 7;21(23):9332. doi: 10.3390/ijms21239332. PMID: 33297592; PMCID: PMC7730342.
  • Tamura N, Shaikh N, Muliaditan D, Soliman TN, McGuinness JR, Maniati E, Moralli D, Durin MA, Green CM, Balkwill FR, Wang J, Curtius K, McClelland SE. Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma. Cancer Res. 2020 Nov 15;80(22):4946-4959. doi: 10.1158/0008-5472.CAN-19-0852. Epub 2020 Sep 30. PMID: 32998996.
  • Yeow ZY, Lambrus BG, Marlow R, Zhan KH, Durin MA, Evans LT, Scott PM, Phan T, Park E, Ruiz LA, Moralli D, Knight EG, Badder LM, Novo D, Haider S, Green CM, Tutt ANJ, Lord CJ, Chapman JR, Holland AJ. Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer. Nature. 2020 Sep;585(7825):447-452. doi: 10.1038/s41586-020-2690-1. Epub 2020 Sep 9. PMID: 32908313; PMCID: PMC7597367.
  • Rayner E, Durin MA, Thomas R, Moralli D, O'Cathail SM, Tomlinson I, Green CM, Lewis A. CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods. CRISPR J. 2019 Dec;2(6):406-416. doi: 10.1089/crispr.2019.0006. Epub 2019 Nov 19. PMID: 31742432; PMCID: PMC6919265.